Received: 22.02.2026
Accepted: 15.03.2026
Published online: 30.03.2026
UDC: 616.311.2-003.93-085:615.322
DOI: 10.70113/1815-9443.2026.41.16.004
CLINICAL EFFICACY OF POLYPHYTO OIL IN THE COMPLEX THERAPY OF LEUKOPLAKIA AND TRAUMATIC EROSIONS OF THE ORAL MUCOSA
Kopbayeva M.T. ¹, Sakipova Z.B. ¹, Kulmanbetov R.I. ¹, Orynbekova S.O. ¹, Jakiyanov A.M. ¹, Kubash A.O. ¹
¹Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Introduction. Oral mucosal pathology, including leukoplakia and erosive lesions, remains an important problem in modern dentistry due to its chronic course, frequent recurrence, impaired keratinization, and negative impact on patients’ quality of life. The problem is particularly relevant in patients with fixed orthodontic appliances, in whom chronic mechanical irritation maintains inflammation and delays tissue repair. Polyphyto oils are considered promising agents for
topical therapy because of their anti-inflammatory, regenerative, and keratoplastic properties.
Objective. To evaluate the clinical efficacy of the polyphyto oil “Fitoleum 9 Herbs” in the complex treatment of oral leukoplakia and traumatic erosive lesions of the oral mucosa, including patients with fixed orthodontic appliances.
Materials and methods. A total of 32 patients aged 18 to 58 years were examined. Oral leukoplakia was diagnosed in 12 (37.5%) patients, while traumatic erosive lesions were found in 20 (62.5%) patients; among them, 11 (55.0%) had fixed orthodontic appliances. Two study groups were formed: the main group included 17 patients who received applications of the polyphyto oil “Fitoleum 9 Herbs” as part of complex therapy, and the control group included 15 patients who received a comparable treatment regimen with sea buckthorn oil. In both groups, oral sanitation was performed when indicated, local traumatic factors were eliminated, and lesions were treated with 0.05% chlorhexidine solution. Treatment efficacy was assessed by lesion area, severity of hyperemia and edema, pain intensity using a visual analogue scale, time to complete epithelialization, and signs of keratoplastic effect. Statistical analysis was performed using Student’s t-test, with p < 0.05 considered significant. Results. The addition of polyphyto oil to complex therapy was associated with a more pronounced positive clinical response compared with the control group. The mean epithelialization time in the main group was 3.7 ± 0.18 days versus 4.8 ± 0.26 days in the control group. Pain relief in patients with erosive lesions was observed on day 2 in the main group and on day 3 in the control group. Reduction of oral mucosal hyperemia reached 50% in the main group compared with 35% in the control group. Keratoplastic activity was also higher in the main group, amounting to 2.8 ± 0.2 versus 1.9 ± 0.3 in the control group. The most pronounced clinical effect was observed in patients with fixed orthodontic appliances.
Discussion. The obtained findings indicate that incorporation of polyphyto oil into the standard treatment regimen may accelerate reparative processes, reduce inflammatory manifestations, and promote faster restoration of the oral epithelial lining. The observed effect is likely related to the combined anti-inflammatory, regenerative, and keratoplastic action of the product components. This is especially important under conditions of during orthodontic treatment. The findings support further investigation of polyphyto oil as a component of topical complex therapy for oral mucosal diseases.
Conclusion. “Fitoleum 9 Herbs” polyphyto oil demonstrated higher clinical efficacy than sea buckthorn oil as part of the complex treatment of oral leukoplakia and traumatic erosive lesions. Its use contributed to shorter epithelialization time, reduction of inflammatory manifestations, and enhanced keratoplastic effect, including in patients with fixed orthodontic appliances.
Keywords: oral mucosa, leukoplakia, traumatic erosive lesions, polyphyto oil, epithelialization, keratoplastic effect, fixed orthodontic appliances.
