Received: 7.11.2025
Accepted: 10.12.2025
Published online: 30.12.2025
UDC: 616.314-089.27
DOI: 10.70113/1815-9443.2025.79.50.004
CLINICAL ORAL MANIFESTATIONS OF SYSTEMIC AND INFECTIOUS DISEASES: DIAGNOSTIC AND PREDICTIVE VALUE
Irina Aleksandrovna Belenova, Karina Sergeevna Tikhonovskaya, Diana Gurgenovna Kazaryan, Aleksey Nikolaevich Morozov, Olesya Borisovna Popova, Kudryavtsev Oleg Alexandrovich
N.N.Burdenko Voronezh State Medical University, Voronezh, Russian Federation
Introduction. In the context of the increasing prevalence of systemic and infectious diseases, including coronavirus infection COVID-19, early identification of their clinical manifestations in the oral cavity is of particular importance. The oral mucosa and dental hard tissues often reflect systemic alterations and may serve as additional diagnostic indicators.
Aim. To evaluate clinical manifestations of systemic and infectious diseases in the oral cavity and to assess the diagnostic and preventive value of dental signs in contemporary clinical practice.
Materials and Methods. The study included a clinical and laboratory assessment of oral conditions in patients with systemic and infectious diseases, including those with a history of COVID-19. Oral fluid pH, enamel acid solubility, dental hard tissue status, and the dynamics of clinical manifestations under individualized preventive approaches were analyzed.
Results. Alterations in oral fluid pH and increased enamel acid solubility were found to correlate with the presence and severity of systemic and infectious conditions. Individualized selection of oral hygiene products based on oral fluid pH contributed to stabilization of acid–base balance and reduction of demineralization processes. Additional preventive measures provided enhanced clinical outcomes.
Conclusion. Oral clinical manifestations represent a valuable component of comprehensive diagnostics of systemic and infectious diseases. An individualized preventive approach improves the effectiveness of dental management and reduces the risk of oral complications.
Key words: oral manifestations; systemic diseases; infectious diseases; diagnostic value; predictive medicine; dental practice, Covid-19
